When comparing Seachem Prime and Seachem Safe, each has its pros and downsides.

Seachem Prime VS Safe

Seachem Prime

Seachem prime removes chlorine and chloramine from the tank water, ammonia, nitrites, and nitrates. It also detoxifies heavy metals. Your fish slime coats will also benefit from the antibacterial properties in the formula. If you have a tank containing less than 50 gallons of water, prime is more convenient to use in terms of dosage.

Seachem Safe

Seachem Safe’s primary advantage is its affordability. Up to 60,000 gallons can be treated by a compact five′′ tall 250 g container, which is 50% more than the giant Seachem Prime bottle. Safe may be a better option if you have a lot of large tanks that need to be treated for chlorine, chloramine, ammonia, nitrites, and/or nitrates.

Similar Functions – Seachem Prime VS Safe

There are a lot of similarities between Seachem Prime and Seachem Safe.

Remove Chlorine/Chloramine from your water

Dechlorination is the primary function of both products.

Chlorine and chloramine are removed from water using both of these products. Disinfectants (chlorine and chloramine) are added to the supply to ensure drinking water is free of dangerous parasites.

As a result, fish and the beneficial microorganisms in your tank water might be killed by the same toxins. So, if you’re adding water to your fish tank for the first time or doing a water change, you’ll probably need a de-chlorinator.

You can safely use Seachem conditioners to convert hazardous ammonia into harmless nitrites and nitrates for your fish. Beneficial bacteria will continue to feed on the nitrogen molecules they have been transformed into.

It’s important to remember that both Seachem Prime and Seachem Safe will only be effective for 48 hours at removing ammonia, nitrites, and nitrates from the water. Re-dosing every 24 hours means you don’t have to wait for your beneficial bacteria colonies to multiply to handle the different nitrogen compounds.

Remove Ammonia, Nitrate, and Nitrite from the Environment

Nitrogen compounds in your fish tank can also be removed by using Prime and Safe. It is ammonia that is hazardous to your fish when organic matter, such as fish food and fish feces, breaks down.                               

Ammonia can be converted to nitrites by the helpful microorganisms stated before. Fortunately, another set of bacteria can convert nitrites to nitrates, which are far more stable. On the other hand, nitrates can harm your fish if they are exposed to water with nitrate concentrations greater than 40 ppm.

Features of Seachem Prime that are not available elsewhere

A few unique aspects of the Seachem Prime are unavailable in Seachem Safe.

Heavy Metal Detoxification

For example, Prime has the potential to remove harmful heavy metals from your fish tank, whereas Safe is unable to do this. Cupro-lead-mercury is some of the more well-known poisons.

Promote the Growth of Natural Slime Coats

Additionally, Seachem Prime’s formula causes a physiological reaction in your fish, causing them to generate extra mucus that encircles them. The fish’s slime covering will serve as a barrier against disease.

Dropper, Cap, or Scoop.

A dropper is included in Seachem Prime’s 50 mL bottle. To close off larger bottles (such as those in the 100-milliliter to four-liter ranges): (the same one utilized to keep the bottles shut).

All Seachem Safe containers are supposed to have a scoop (50 g, 250 g, 1 kilogram, and 4 kg). Despite this, some users claim the product doesn’t include one.

For this reason, Seachem Prime benefits from the doubt because of the lack of a scoop in Seachem Safe.


The amount of Prime/Safe dose you can put in your tank varies depending on the brand and container size.

Due to the 50 mL bottle per gallon accuracy, Seachem Prime is preferable for dosing smaller fish tanks.

Fifty gallons of Seachem Safe can be treated with just one scoop. As a result, if you have a smaller tank, you will need to carefully divide the dose amount from the scoop with the kit.

For Prime and Safe, you can find the recommended dosages below.

How to use Seachem Prime in 50 mL

Two drops of Ammonia/Nitrate/Nitrite per 1 gallon of water is the recommended dosage (or 4 liters). In an emergency, you can use up to ten drops per gallon to detoxify nitrite (or 4 liters).

To eliminate the Chloramine in the Water, use four drops per gallon of water (or 4 liters).

A temperature above 86°F (or 30°C) is required to remove low amounts of chlorine and decontaminate ammonia. Per 1 gallon of water, add one drop (or 4 liters)

Seachem Prime 100 mL, 250 mL , 500 mL , 1 L, 2 L, and 4 L Dosing Instructions: :
Detoxify by removing chlorine/chloramine from the environment. A 50-milliliter dose of ammonia, nitrate, or nitrite (or 200 liters)

Eliminate the Chloramine in the Water. 100 mL per 50 gallons of solution (or 200 liters)
Nitrite Detoxification: 250 mL per 50 gallons (or 200 liters).

With temperatures above 86 °F (or 30 °C), 25 mL per 50 gallons of water can be used to remove low amounts of chlorine and detoxify ammonia (or 200 liters)

50 g Dosing instructions for Seachem Safe
To remove chlorine/chloramine, use 200 milligrams per 50 gallons of water (or 200 liters)
200 milligrams per 13 liters of water for Ammonia detoxification (or 50 liters)
Chloramine concentrations over 400 mg per 50 gallons should be eliminated (or 200 liters)
In an emergency, you can detoxify with up to 800 mg of nitrite or nitrate per 50 gallons of water (or 200 liters)
With a temperature above 86°F (or 30°C), remove low levels of chlorine and detoxify ammonia: 100 mg per 50 gallons (or 200 liters)


I am Bruce Daniel Holgate from Los Angeles, the founder of aquariumbee.com, environmental scientist and content writer. Researcher and hobbyist in aquarium keeping and fish breeding with 20 years of experience. I'm willing to share my knowledge with you all.

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